Results

Key publications and outcomes from the ATHENA project

Wagenaars F et al. Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay. Toxicol In Vitro. Vol 96, 105770. Apr 2024, https://doi.org/10.1016/j.tiv.2023.105770
Forner-Piquer et al. Disruption of the thyroid hormone system and patterns of altered thyroid hormone after gestational chemical exposures in rodents – a systematic review. Frontiers in Endocrinology. Vol 14:1323284. Jan 2024, https://doi.org/10.3389/fendo.2023.1323284
Derakhshan A et al. Association of endocrine disrupting chemicals exposure with human chorionic gonadotropin concentrations in pregnancy. Environment International. Vol 178, 108091. Aug 2023. https://doi.org/10.1016/j.envint.2023.108091
Chen Z et al. Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family. Eur Thyroid J. Vol 12. Jun 2023, https://doi.org/10.1530/ETJ-23-0023
Chen Z et al. Asymmetrical Transport of Thyroxine Across Human Term Placenta. Thyroid. Vol 33. May 2023, https://doi.org/10.1089/thy.2022.0406
Vancamp P & Remaud S. Developmental exposure to thyroid disruptors: mis-programming of the brain’s stem cells in later life? Neural Regen Res. Vol 18, 527-528 Mar 2023 https://doi.org/10.4103/1673-5374.346053
Vancamp P et al. Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Environment International. Vol 172: 107770. Feb 2023, https://doi.org/10.1016/j.envint.2023.107770
Köhrle J. Selenium, Iodine and Iron-Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism. Int J Mol Sci. Vol 24, 3393. Feb 2023, https://doi.org/10.3390/ijms24043393
Gerhardt et al. Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle. Scientific Reports Vol 13, 3122. Feb 2023 https://doi.org/10.1038/s41598-023-30179-w
Leemans M et al. A mixture of chemicals found in human amniotic fluid disrupts brain gene expression and behaviour in Xenopus laevis. Int. J. Mol. Sci. Vol 24 (3): 2588. Jan 2023, https://doi.org/10.3390/ijms24032588
Köhrle J & Frädrich C. Deiodinases control local cellular and systemic thyroid hormone availability. Free Radical Biology and Medicine. Vol 193, 59-79, Nov 2022. https://doi.org/10.1016/j.freeradbiomed.2022.09.024
Derakhshan A et al. Association of per- and polyfluoroalkyl substances with thyroid homeostasis during pregnancy in the SELMA study. Environment International. Vol 167, 107420. Sep 2022 https://doi.org/10.1016/j.envint.2022.107420
Chen Z et al. Thyroid Hormone Transporters in a Human Placental Cell Model. Thyroid. Vol 32, 1129-1137. Sep 2022, https://doi.org/10.1089/thy.2021.0503
Vancamp P et al. Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone. Stem Cell Reports. Vol 17, 459-474. Mar 2022. https://doi.org/10.1016/j.stemcr.2022.01.002
Renko K et al. Tentative application of a streamlined protocol to determine organ-specific regulations of deiodinase 1 and dehalogenase activities as readouts of the hypothalamus-pituitary-thyroid-periphery axis. Frontiers in Toxicology. Vol 4, article 822993. March 2022 https://www.frontiersin.org/articles/10.3389/ftox.2022.822993/full
Ramhøj et al. Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring. Toxicology Letters. Vol 354, 44-55. Jan 2022. https://doi.org/10.1016/j.toxlet.2021.10.010
Derakhshan A et al. Association of phthalate exposure with thyroid function during pregnancy. Environment International. Vol 157, 106795. December 2021. https://doi.org/10.1016/j.envint.2021.106795
Ramhøj et al. Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase. Environmental Pollution. Vol 283, 117135. August 2021. https://doi.org/10.1016/j.envpol.2021.117135
Delphosse V et al. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. PNAS. Vol 118. January 2021. https://doi.org/10.1073/pnas.2020551118
Derakhshan A et al. Association of urinary bisphenols during pregnancy with maternal, cord blood and childhood thyroid function. Environment International. Vol 146, 106160. January 2021. https://doi.org/10.1016/j.envint.2020.106160
Demeneix B, Vandenberg LN, Ivell R, Zoeller RT. Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective. Journal of the Endocrine Society 4:10, October 2020. https://doi.org/10.1210/jendso/bvaa085
Gilbert ME, O’Shaughnessy KL, Axelstad M. Regulation of Thyroid-disrupting Chemicals to Protect the Developing Brain. Endocrinology 161. Issue 10. October 2020. https://doi.org/10.1210/endocr/bqaa106
Kortenkamp A et al. Removing Critical Gaps in Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals – The ATHENA Project. International Journal of Molecular Sciences. Vol 21(9), 3123. April 2020. https://www.mdpi.com/1422-0067/21/9/3123
Stephan Couderq, Michelle Leemans, Jean-Baptiste Fini. Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models. Molecular and Cellular Endocrinology, Vol 508, 110779. May 2020 https://doi.org/10.1016/j.mce.2020.110779
Derakhshan A, Shu H, Peeters RP, Kortenkamp A, Lindh CH, Demeneix B, Bornehag C-G, Korevaar TIM. Association of urinary bisphenols and triclosan with thyroid function during early pregnancy. Environment International, Vol 133. December 2019. https://doi.org/10.1016/j.envint.2019.105123

The models described in Chinen et al can also be applied to the ATHENA project:

Chinen KK, Klimenko K, Taxvig C, Nikolov NG, Wedebye EB. QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S substances. Computational Toxicology, Vol 14, 10021. May 2020. https://doi.org/10.1016/j.comtox.2020.100121